Build a Signaling Pathway

Part A

Which of these is a logical signal transduction pathway?

An ion-channel receptor opens, allowing a steroid hormone to enter the cell; the steroid hormone then activates protein kinases that convert GTP to GDP, which binds to an intracellular enzyme that carries out a response.

A receptor tyrosine kinase activates adenylyl cyclase, which activates phospholipase C, which converts ATP into cyclic AMP, which binds to an intracellular enzyme that carries out a response.

A G-protein-linked receptor activates G protein, which activates phospholipase C, which cleaves a membrane lipid to form IP3, which binds to a calcium channel on the ER, which opens to release calcium ions into the cytoplasm, which bind to an intracellular enzyme that carries out a response.

An intracellular receptor activates phospholipase C, which cleaves a membrane protein to form IP3, which then activates the opening of an ER channel protein, which releases cyclic AMP into the cytoplasm, where it binds to an intracellular enzyme that carries out a response.

Correct

This is a logical sequence.

Build a Signaling Pathway

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